Pathology
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Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
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ExpSys: non-tumors
ExpSys: tumors
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
IgA linear dermatosis
Clinical signs
  • two forms of the disease:
    • adult type
    • childhood type
  • adult form has clinical features similar to dermatitis herpetiformis, less pruritic; childhood form presents as polycyclic vesicles, distributed over abdomen, genitalia, buttock and periorally.
Histology

Histology is the same in both forms and resembles dermatitis herpetiformis: subepidermal vesicles, edema, accumulation of neutrophils. The distribution of the neutrophils is not limited to papillae, but is present along the dermo-epidermal border. Similarly, the fluorescence shows linearly arranged subepidermal deposits.

Pictures

IgA linear dermatosis (paraffin section, frozen section and corresponding direct fluorescence slides): Linear IgA dermatosis, HE 40x (2688) Linear IgA dermatosis, frozen section, frozen HE 40x (2687) Linear IgA dermatosis, anti-IgA, FITC 20x (2690) Linear IgA dermatosis, anti-IgA, FITC 40x (2693) Linear IgA dermatosis, anti-IgG, FITC 40x (2695) Linear IgA dermatosis, anti-IgM, FITC 40x (2696) Linear IgA dermatosis, anti-fibrin, FITC 20x (2689)

Another case: Linear IgA dermatosis, HE 20x (1349) Linear IgA dermatosis, HE 40x (1350)

Another case: Linear IgA dermatosis, HE 40x (4127)

IgA linear dermatitis, 15 years old girl, sometimes presenting with vesicles. Neutrophils are distributed along the basal membrane: Linear IgA dermatosis, HE 40x (5954) Linear IgA dermatosis, HE 40x (5953)

IgA linear dermatitis, child: Linear IgA dermatosis of children, HE 20x (4711)

Linear IgA dermatitis: Linear IgA dermatosis, HE 20x (5173)

Linear IgA dermatitis: IgA linear dermatitis, HE 60x (10037)