Pathology
Images
Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Keratoacanthoma
Clinical signs
  • location: usually face or dorsa of the hands
  • solitary lesion, rarely multiple
  • firm papule, central crater filled with keration
  • fast growth, spontaneous regression possible

Keratoacanthoma (1062)

Histology

Hyperkeratotic papule, formed by central keratinous plug surrounded by proliferating, atypical epidermal invagination. Dysplastic epidermis shows changes corresponding to the well differentiated squamous carcinoma, but cytoplasm is usually more eosinophilic. Mitotic activity is usually high, especially in early lesions. Epithel shows focal necroses and neutrophilic or eosinophilic microabscesses. At the base of the lesion there is usually dense lymphocytic infiltrate, often with admixture of eosinophils. At periphery the tumor shows limited infiltrating behavior.

Keratoacanthoma (10215)