Pathology
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Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Intravascular B lymphoma
Clinical signs
  • very rare disease
  • erythematous and violaceous plaques or nodules
  • location: face, trunk, extremities (and other organs)
  • neurological defects are common
  • bad prognosis
Histology

Dense proliferation of atypical, usually large lymphoid cells with round or oval nuclei within the lumina of blood vessels. Blood vessels may get occluded or thrombosed. Mitoses are frequent. Spread into surrounding tissue occurs.

Immunophenotype and genetic features:

  • B markers, sometimes CD5, CD10, CD11a, and CD49d
  • bcl-2 overexpression was found in most cases
  • Cases of identical appearance but with T phenotype were described.

Intravascular B lymphoma (4274)