Atlas of dermatopathology: Pemphigus vulgaris and its variants (immunofluorescence)

+ Introduction

+ Literature

+ Support

+ Skin biopsy

+ Non-tumorous skin diseases

+ Skin tumors

+ Mesenchymal tumors

+ Cysts of the skin and subcutis

+ Soft tissue lesions

+ Some lesions of the oral cavity

+ Dermatovenerology

+ Collection of histological slides by prof. Günter Burg

+ Collection of histological slides by prof. Werner Kempf

+ Collection of histological slides of dr. Ram Chandra Adhikari

Pemphigus vulgaris and its variants (immunofluorescence)

Introduction

Direct immunofluorescence contributes to the diagnosis of pemphigus vulgaris, pemphigus vegetans, pemphigus foliaceus and pemphigus erythematosus significantly by detection of autoantibodies bound to desmosomal areas (IgG, c3).

Pictures

Net-like positivity of the surface of keratinocytes is common: Pemphigus vulgaris, anti-ics, FITC 20x (10) Pemphigus vulgaris, FITC, Evans 40x (1910) Pemphigus vulgaris, anti-IgG, FITC, Evans 40x (1913) Pemphigus vulgaris, anti-IgG, FITC, Evans 40x (1914) Pemphigus vulgaris, anti-IgG, FITC, Evans 100x (1911) Pemphigus vulgaris, anti-IgG, FITC, Evans 100x (1912)

Net-like positivity of the surface of keratinocytes, esophagus, guinea pig, pemphigus vegetans: Pemphigus vegetans, indirect IF, FITC 10x (3676) Pemphigus vegetans, indirect IF, FITC 20x (3677) Pemphigus vegetans, indirect IF, FITC 20x (3678) Pemphigus vegetans, indirect IF, FITC 40x (3679) Pemphigus vegetans, indirect IF, FITC 40x (3680)

Pemphigus vulgaris, low titre, where positivity is limited to the lower areas of the epidermis: Pemphigus vulgaris, low titre, anti-IgG, FITC, Evans 40x (2005) Pemphigus vulgaris, low titre, anti-IgG, FITC, Evans 40x (2006) Pemphigus vulgaris, low titre, anti-IgG, FITC, Evans 40x (2007)

Pemphigus vulgaris: Pemphigus vulgaris, FITC 10x (6026) Pemphigus vulgaris, FITC 20x (6028) Pemphigus vulgaris, FITC 40x (6027) Pemphigus vulgaris, FITC 40x (6029)

Pemphigus foliaceus gives positivity in the upper third of the epidermis: Pemphigus foliaceus, anti-ics, FITC 20x (11)

Pemphigus foliaceus (another case): Pemphigus foliaceus, anti-IgG, FITC 20x (1974) Pemphigus foliaceus, anti-IgG, FITC 40x (1975) Pemphigus foliaceus, anti-IgG, FITC 40x (1976)

Pemphigus foliaceus (another case): Pemphigus foliaceus developed, anti-ig, FITC 20x (2241) Pemphigus foliaceus developed, anti-ig, FITC 40x (2242) Pemphigus foliaceus developed, anti-ig, FITC 40x (2243)

Pemphigus erythematosus can show the lupus band in some cases: m. Senear-Usher, FITC (12)

ICS antibodies are not found in Hailey-Hailey disease.

Cases after therapy (high doses of steroids and cytostatics) may show negative results.