Pathology
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Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
Index
Contents
Authors
ExpSys: non-tumors
ExpSys: tumors
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Graft versus host reaction
Clinical signs
  • affects patients after bone marrow transplantation, rarely after blood transfusion and very rarely in newborns
  • acute forms occur about 3 weeks after the transplantation: skin lesions, diarrhea, liver dysfunction
  • chronic forms occur 3 months after the transplantation: skin lesions (lichenoid lesions, hyperpigmentations, sclerosis, atrophy)
Histology

Acute forms are graded: grade 1 (vacuolization along the basal layer); grade 2 (dyskeratosis, exocytosis, necrotic keratinocytes); grade 3 (subepidermal clefting); grade 4 (bullae, loss of the epidermis).

Chronic forms there is lichenoid infiltrate, loss of polarization of the epidermis, necrotic keratinocytes, pigment incontinence, atrophy and dermal sclerosis.

Pictures

Graft versus host reaction. gr. IV.: Graft versus host, severe bullous reaction, HE 10x (1774) Graft versus host, severe bullous reaction, HE 20x (1775)

Another case: Graft versus host reaction, HE 10x (1776) Graft versus host reaction, HE 40x (1778)

Graft versus host reaction after bone marrow transplantation in acute myeloic leukemia: Graft versus host nonbullous, HE 40x (2213)

Another case: Graft versus host reaction, HE 40x (2678)

Another case: Graft versus host: nonbullous, HE 40x (3490)

GVHD, gr. II.: Graft versus host gr. II., HE 40x (4105)

Another case: Graft versus host, HE 40x (4122)

Acute GVHD: Graft versus host, acute, nonbullous GVHD, HE 20x (4322)

Acute GVHD, gr. IV., erythema multiforme-like: Graft versus host disease, erythema multiforme-like, HE 60x (12011)

GVHD, sclerotic type: Graft versus host, sclerosing GVHD, HE 20x (4506)

Another example of sclerotic GVHD: Graft versus host, sclerosing GVHD, HE 20x (4507)

Another case of chronic sclerodermiform GVHD (autopsy): Chronic GVHD, HE 40x (10187)

Lichenoid GVHD: Graft versus host, lichenoid GVHD, HE 20x (4504)

GVHD, grade II.: Graft versus host, nonbullous GVHD, HE 100x (5447)