Pathology
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Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
Index
Contents
Authors
ExpSys: non-tumors
ExpSys: tumors
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Erythema nodosum
Etiology, pathogenesis
  • triggered by infection, drugs...
  • probably immonologic in basis
Clinical signs
  • dome shaped nodules, especially on lower limbs, but sometimes on the thighs and upper extremities
  • palpable subcutaneous nodules, size over 1 cm
  • red or purple color
  • tender or painful on palpation
  • never ulcerate
  • self-limited, nodules eventually heal
  • peak incidence in women, 3rd decade
Pictures

Erythema nodosum: Erythema nodosum, Clinical picture (730)

Erythema nodosum: Erythema nodosum, Clinical picture (731)

Erythema nodosum: Erythema nodosum, Clinical picture (732)

Erythema nodosum: Erythema nodosum, Clinical picture (2916)

Erythema nodosum: Erythema nodosum, Clinical picture (2917) Erythema nodosum, Clinical picture (2918)

Further examples of erythema nodosum:

Histology

Inflammation of fibrous septa between fat lobules; variably spreading into the lobules. Lymphocytes and macrophages dominate, neutrophils are often admixtured. Giant cells of foreign body type are located around clefts in collagen. Miescher granuloma is formed by more or less radially arranged macrophages, often around cleft like defects of dermal collagen.

Pictures

Erythema nodosum: Erythema nodosum, HE 5x (228) Erythema nodosum, HE 10x (224) Erythema nodosum, HE 10x (225) Erythema nodosum, HE 20x (226) Erythema nodosum, HE 40x (227) Erythema nodosum, Miescher's granuloma, HE 100x (223)

Erythema nodosum: Erythema nodosum, HE 60x (10667)

Erythema nodosum, predominantly septal panniculitis with Miescher's granulomas: Erythema nodosum, HE 60x (12283)

Erythema nodosum: Erythema nodosum, HE 20x (12047)

Another case: Erythema nodosum, HE 20x (222)

Another case: Erythema nodosum, HE 10x (2353) Erythema nodosum, HE 10x (2354)

Another case: Erythema nodosum, HE 60x (13772)

Erythema nodosum: Erythema nodosum, HE 60x (13883) Erythema nodosum, elastic fibres 60x (13882)

Early erythema nodosum: Erythema nodosum, HE 20x (3484) Erythema nodosum, HE 40x (3485)

Early erythema nodosum, another case: Erythema nodosum, early, HE 40x (5482)

Erythema nodosum in a patient with Crohn's disease: Erythema nodosum, Crohn's disease, HE 40x (5494)

Erythema nodosum: Erythema nodosum, HE 20x (5129)