Atlas of dermatopathology: Dermatofibroma (histiocytoma of the skin)

+ Introduction

+ Literature

+ Support

+ Skin biopsy

+ Non-tumorous skin diseases

+ Skin tumors

+ Mesenchymal tumors

+ Cysts of the skin and subcutis

+ Soft tissue lesions

+ Some lesions of the oral cavity

+ Dermatovenerology

+ Collection of histological slides by prof. Günter Burg

+ Collection of histological slides by prof. Werner Kempf

+ Collection of histological slides of dr. Ram Chandra Adhikari

Dermatofibroma (histiocytoma of the skin)

Clinical signs

common process, occurs anywhere, often on the extremities
usually solitary nodule, firm, roundish, sometimes polypoid
color: pink, brown, yellowish

Dermatofibroma (5576)

Dermatofibroma (3750)

Pictures

Dermatofibroma: Dermatofibroma, Macro (3747) Dermatofibroma, Macro (3748) Dermatofibroma, Macro (3749) Dermatofibroma, Macro (3750) Dermatofibroma, Clinical picture (5575) Dermatofibroma, Clinical picture (5576)

Further examples of dermatofibroma:

Histology

Variable appearance with participation of fibroblasts, blood vessels, mature connective tissue. Foamy macrophages (and Touton cells), siderophages and lymphocytes are present as well. The structure is sometimes storiform. Borders are unsharp, usually with typical entrapment of collagen fibres. Mature forms are composed mostly of mature collagen.

Acanthotic proliferation of the overlying epidermis is common, often with increased pigmentation (melanin) and sometimes with follicular induction (which may resemble superficial basalioma).

Less common are cellular histiocytomas, rare are aneurysmatic and epithelioid forms.

Dermatofibroma (2623)

Dermatofibroma (12064)

Dermatofibroma (3655)

Dermatofibroma (4878)

Dermatofibroma (5154)

Dermatofibroma (10567)

Dermatofibroma (13635)

Aneurysmatic histiocytoma (5444)

Pictures

Dermatofibroma: Dermatofibroma, HE 40x (2623)

Another case: Dermatofibroma, HE 40x (2624)

Another case: Dermatofibroma, HE 40x (4792)

Another case: Dermatofibroma, HE 60x (10568)

Another case: Dermatofibroma, HE 40x (12664)

Another case: Dermatofibroma, HE 40x (12665)

Another case: Dermatofibroma, HE 60x (10660)

Dermatofibroma around dilated follicle: Dermatofibroma around dilated follicle, HE 20x (14044)

Old dermatofibroma: Dermatofibroma, HE 20x (2208)

Large, cellular histiocytoma: Cellular histiocytoma, large, HE 10x (2683) Cellular histiocytoma, large, HE 40x (2684)

Another example of a large histiocytoma: Dermatofibroma, large, HE 40x (3615) Dermatofibroma, large, Prussian blue 40x (3614) Histiocytoma, large, CD68 40x (3628) Histiocytoma, large, Ki67 40x (3629)

Another case of large histiocytoma: Dermatofibroma, HE 20x (3659) Dermatofibroma, HE 40x (3660)

Cellular dermatofibroma: Cellular dermatofibroma, HE 60x (10567)

Cellular dermatofibroma: Cellular histiocytoma, HE 60x (10992)

Dermatofibroma with pseudoepithelimatous hyperplasia: Histiocytoma with pseudoepitheliomatous hyperplasia, HE 60x (12063)

Dermatofibroma with hemosiderin deposits and giant cells: Histiocytoma with giant cells, HE 40x (12064)

Dermatofibroma with prominent deposits of hemosiderin: Dermatofibroma with prominent deposits of hemosiderin, HE 40x (3528)

Another case of a large dermatofibroma with prominent deposits of hemosiderin (black histiocytoma): Black histiocytoma, HE 20x (4842) Black histiocytoma, HE 40x (4764) Black histiocytoma, Prussian blue 40x (4763)

Dermatofibroma of a patient with primary hemochromatosis, heavy hemosiderin pigmentation: Dermatofibroma, patient with hemochromatosis, HE 20x (3560) Dermatofibroma, patient with hemochromatosis, Prussian blue 20x (3559)

Dermatofibroma with follicular induction: Dermatofibroma with follicular induction, HE 20x (3655) Dermatofibroma with follicular induction, HE 40x (3656)

Keloidal dermatofibroma: Dermatofibroma, keloidal, HE 40x (4878)

Dermatofibroma, atrophy: Dermatofibroma, atrophic, HE 20x (5457)

Dermatofibroma with mucin accumulation: Dermatofibroma, mucinous = vyradit, je to asi nevus, HE 40x (5030) Dermatofibroma, mucinous = vyradit, je to asi nevus, Halle 20x (5029)

Dermatofibroma: Dermatofibroma, HE 40x (12282)

Cellular histiocytoma with monster cells: Dermatofibroma with monster cells, HE 40x (5154)

Aneurysmatic histiocytoma: Aneurysmatic histiocytoma, HE 20x (5444) Aneurysmatic histiocytoma, HE 40x (5445) Aneurysmatic histiocytoma, CD34 40x (5442)

Epithelioid histiocytoma: Epitheloid histiocytoma, HE 60x (6402) Epitheloid histiocytoma, CD68 60x (6401)

Epithelioid histiocytoma: Epitheloid histiocytoma, HE 60x (14536)

Epithelioid histiocytoma: Epitheloid histiocytoma, HE 60x (13635)

Scarring histiocytoma: Scarring dermatofibroma, HE 40x (5446)

Dermatofibroma combined with seborrhoic keratosis (serial sections): Dermatofibroma and seborrhoic keratosis, HE 20x (13448) Dermatofibroma and seborrhoic keratosis, HE 20x (13449)

Cellular dermatofibroma: Cellular dermatofibroma, HE 60x (14053)

Dermatofibroma, cellular, diff. dg. fibrosarcoma: Dermatofibroma or fibrosarcoma, HE 20x (13771)