Pathology
Images
Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Cryptococcosis
Etiology

Caused by the fungus Cryptococcus neoformans.

Clinical signs
  • variable papules, pustules, nodules, abscesses, ulcers
  • + systemic manifestations (respiratory tract, CNS, bones, prostate, kidneys, lymphnodes)
  • may be widespread
Histology

Roundish spore, 4 – 12 µm with (but only 2 – 4 µm without) capsule. The gelatinous capsule stains with alcian blue, PAS and mucicarmine. Granulomatous inflammation (histiocytes, lymphocytes, giant cells, necrosis) is usually present (less inflammation when forms with gelatious capsules dominate).