Pathology
Images
Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
×
+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Chondroid syringoma
Clinical signs
  • firm subcutaneous nodules
  • size up to 2 cm
Histology

Roundish tumor, benign, often separated from surrounding dermis by a cleft. Also called mixed tumor of the skin (usually contains areas of chondroid appearance). Two forms are recognized: tubular and branching (apocrine) and form with small tubular lumina (probably eccrine). The tumor cells are CEA positive.

Apocrine variant is more common; epithelium is high, basophilic, two layered epithelium; forming duct-like and cystic structures and epithelial nests. The outer layer of the ducts is vimentin positive. Stroma contains mucin and often is of chondroid appearance. Epithelium sometimes shows decapitation secretion.

Eccrine variant consists of roundish tubules lined with single layer of epithelial cells. Stroma contains mucin; chondroid changes are less apparent than in apocrine type.

Chondroid syringoma (1992)

Chondroid syringoma (6386)