Pathology
Images
Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Burkitt lymphoma
Clinical signs
  • affects children in equatorial Africa and sporadically children and young adults in other countries
  • affects immunodeficient patients as well
  • extranodal forms (bones of the face, abdomen), leukemisation
  • secondary infiltration of the skin occurrs rarely
  • aggressive, responsive to therapy
Histology

Diffuse homogenous proliferation of middle size lymphoid cells, with large nuclei and narrow cytoplasm, forming dense infiltrates. Among these dark background are pale macrophages scattered, giving the picture of starry sky. No epidermotropism. High mitotic activity.

Immunohistochemistry: CD20+, CD10+, CD5-, bcl-.

Genotype: various generic anomalies (immunoglobulin genes, c-myc and other).

Burkitt lymphoma (4435)

Pictures

Burkitt lymphoma, secondary infiltration of the skin: Burkitt lymphoma, HE 20x (4435)