Pathology
Images
Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Thrombangiitis obliterans (Bürger)
Clinical signs
  • rare, most often in young adults
  • male to female ratio 4:1
  • almost all patients are (heavy) smokers
  • afects any artery, but most common location are peripheral arteries on extremities (fingers, toes)
  • thrombosis, ischemia, necrosis, dry gangrene, amputation (or autoamputation)
Histology

Thrombosis of small or medium arteries and (often as well) veins. Mixed perivascular infiltrate (lymphocytes, neutrophiles, eosinophiles, histiocytes and sometimes giant cells). Microabscesses. Later fibrosis and possibly recanalization.

Histology (especially in late stages) is not specific and clinical correlation is important.