Pathology
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Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
Index
Contents
Authors
ExpSys: non-tumors
ExpSys: tumors
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Bullous pemphigoid
Etiology, pathogenesis
  • autoimmune disease: circulating IgG antibodies bind to lamina lucida of basement membrane
  • antibody binding causes blister formation
Clinical signs
  • elder patients (over 70 years)
  • the trunk, extremities, seldom the head, mucous membranes
  • tense blisters on reddened skin
  • chronic urticarial lesions
  • pruritus, healing without scars

Bullous pemphigoid (3891)

Bullous pemphigoid (3893)

Pictures

Bullous pemphigoid, hemorrhagic bulla: Bullous pemphigoid, Clinical picture (860)

Bullous pemphigoid, healing lesions: Bullous pemphigoid, Clinical picture (861)

Another case: Bullous pemphigoid, Macro (3891) Bullous pemphigoid, Macro (3893) Bullous pemphigoid, Macro (3894) Bullous pemphigoid, Macro (3895) Bullous pemphigoid, Macro (3896)

Another case: Bullous pemphigoid, Clinical picture (5802) Bullous pemphigoid, Clinical picture (5803) Bullous pemphigoid, Clinical picture (5804) Bullous pemphigoid, Clinical picture (5805) Bullous pemphigoid, Clinical picture (5806) Bullous pemphigoid, Clinical picture (5807)

Another case: Bullous pemphigoid, Clinical picture (5808) Bullous pemphigoid, Clinical picture (5809) Bullous pemphigoid, Clinical picture (5810) Bullous pemphigoid, Clinical picture (5811) Bullous pemphigoid, Clinical picture (5812) Bullous pemphigoid, Clinical picture (5813) Bullous pemphigoid, Clinical picture (5814) Bullous pemphigoid, Clinical picture (5815) Bullous pemphigoid, Clinical picture (5816) Bullous pemphigoid, Clinical picture (5817) Bullous pemphigoid, Clinical picture (5818) Bullous pemphigoid, Clinical picture (5819)

Further examples of bullous pemphigoid:

Histology

Subepidermal blisters, roof formed by almost normal epidermis. Vacuolar degeneration of the basal layer. Eosinophils variably admixtured in the superficial dermal infiltrate, often enter the epidermis and usually are present within the bulla (but not in cell poor variant). The base of the blister reepitelises quickly and the blister sometimes becomes intraepidermal. Immunofluorescence: linear deposits of IgG and C3 along the basement membrane.

Bullous pemphigoid (104)

Pictures

Bullous pemphigoid: Bullous pemphigoid, HE 100x (5279)

Bullous pemphigoid: Bullous pemphigoid, HE 20x (102) Bullous pemphigoid, HE 10x (103) Bullous pemphigoid, HE 40x (104)

Bullous pemphigoid: Bullous pemphigoid, HE 40x (4733)

Bullous pemphigoid: Bullous pemphigoid, HE 40x (4734)

Bullous pemphigoid: Bullous pemphigoid, HE 60x (6248)

Bullous pemphigoid: Bullous pemphigoid, HE 60x (11007)

Bullous pemphigoid: Bullous pemphigoid, HE 60x (12112)

Bullous pemphigoid: Bullous pemphigoid, HE 60x (12512)

Bullous pemphigoid: Bullous pemphigoid, HE 40x (12626)

Bullous pemphigoid: Bullous pemphigoid, HE 40x (12627)

Very early lesion: Bullous pemphigoid, early, HE 40x (105)

Another early lesion: Bullous pemphigoid urticarial, HE 40x (569)

Bullous pemphigoid combined with Grover's disease: Bullous pemphogoid and m. Grover, HE 60x (13817)

Further information is found in the chapter Imunofluorescence.