Pathology
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Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
Index
Contents
Authors
ExpSys: non-tumors
ExpSys: tumors
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Anaplastic large cell lymphoma T
Clinical signs
  • solitary or multiple nodules confined to one body compartment
  • no preceeding patches or plaques in most of the cases
  • little epidermal involvement or scaling
  • ulceration and transformation in advanced tumor nodules
Histology

Nodular infiltrate, extending through all levels of the dermis into the subcutis. Epidermotropism is usually present with a few single cells. Tumor cells grow in dense cohesive sheets. Clusters of small reactive lymphocytes are found within and around the tumorous proliferation. Eosinophils, plasma cells and accessory cells are usually lacking.

Large, bizzare cells with large, round, irregularly shaped nuclei, abundant chromatin and one or multiple nucleoli. Cells may be multinucleated. Abundant, clear or eosinophilic cytoplasm.

Immunophenotype and genetic features:

  • CD30+, CD43+, CD45RO+
  • variable loss of pan-T cell antigens (CD2, CD3, CD5), EMA-, CLA+(HECA-452)

Anaplastic large cell lymphoma T (2449)

Anaplastic large cell lymphoma T, CD30 (2189)

Anaplastic large cell lymphoma T (12960)

Anaplastic large cell lymphoma T (6292)

Anaplastic large cell lymphoma T, Ki67 (6264)

Pictures

Anaplastic large cell lymphoma T: Anaplastic large cell lymphoma T, HE 40x (2194) Anaplastic large cell lymphoma T, HE 100x (2450) Anaplastic large cell lymphoma T, HE 100x (2452) Anaplastic large cell lymphoma T, CD30 40x (2193)

Another case: Anaplastic large cell lymphoma T, HE 40x (2192) Anaplastic large cell lymphoma T, HE 100x (2451)

Another case: Anaplastic large cell lymphoma T, HE 40x (2190) Anaplastic large cell lymphoma T, HE 40x (2191) Anaplastic large cell lymphoma T, HE 100x (2449) Anaplastic large cell lymphoma T, CD30 40x (2189)

Another case, high positivity for proliferation marker Ki67: Anaplastic large cell lymphoma T, HE 20x (2790) Anaplastic large cell lymphoma T, HE 40x (2606) Anaplastic large cell lymphoma T, HE 40x (2607) Anaplastic large cell lymphoma T, HE 100x (2599) Anaplastic large cell lymphoma T, HE 100x (2600) Anaplastic large cell lymphoma T, HE 100x (2601) Anaplastic large cell lymphoma T, CD20 40x (2602) Anaplastic large cell lymphoma T, CD3 40x (2603) Anaplastic large cell lymphoma T, CD45ro 40x (2605) Anaplastic large cell lymphoma T, CD30 40x (2604) Anaplastic large cell lymphoma T, HE 20x (2592) Anaplastic large cell lymphoma T, HE 40x (2597) Anaplastic large cell lymphoma T, HE 100x (2591) Anaplastic large cell lymphoma T, CD20 40x (2593) Anaplastic large cell lymphoma T, CD3 40x (2594) Anaplastic large cell lymphoma T, CD30 40x (2595) Anaplastic large cell lymphoma T, CD30 40x (2596) Anaplastic large cell lymphoma T, Ki67 40x (2598)

Anaplastic large cell T lymphoma, convoluted nuclei: Anaplastic large cell lymphoma T (ALCL T), HE 60x (12789)

Anaplastic large cell T lymphoma, convoluted nuclei: Anaplastic large cell lymphoma T (ALCL T), HE 60x (12790)

Anaplastic large cell T lymphoma, convoluted nuclei, CD30+: Anaplastic large cell T lymphoma, CD30 positive, HE 60x (12959) Anaplastic large cell T lymphoma, CD30 positive, HE 40x (12958)

Anaplastic large cell T lymphoma, convoluted nuclei, CD30+: Anaplastic large cell T lymphoma, CD30 positive, HE 60x (12960)

Anaplastic large cell T lymphoma, convoluted nuclei: Anaplastic large cell lymphoma T (ALCL T), HE 40x (12855)

Anaplastic T cell lymphoma: Anaplastic T cell lymphoma, HE 60x (12792)

Anaplastic T cell lymphoma: Anaplastic T cell lymphoma, HE 60x (12793)

Another case: Anaplastic large T cell lymphoma, CD30+, HE 40x (10907) Anaplastic large T cell lymphoma, CD30+, CD3 40x (10905) Anaplastic large T cell lymphoma, CD30+, CD30 40x (10906) Anaplastic large T cell lymphoma, CD30+, Ki67 40x (10908)

CD30+, large T cell lymphoma: Anaplastic large cell lymphoma T, HE 40x (3497) Anaplastic large cell lymphoma T, CD3 40x (3495) Anaplastic large cell lymphoma T, CD20 20x (3493) Anaplastic large cell lymphoma T, CD30 40x (3496) Anaplastic large cell lymphoma T, Ki67 20x (3494)

Another case of CD30 positive large T cell lymphoma: Anaplastic large cell lymphoma T, HE 20x (4135) Anaplastic large cell lymphoma T, HE 40x (4138) Anaplastic large cell lymphoma T, CD3 40x (4136) Anaplastic large cell lymphoma T, CD30 40x (4137) Anaplastic large cell lymphoma T, Ki67 40x (4139)

Another case of CD30 positive large T cell lymphoma: Anaplastic large cell lymphoma T (ALCL T), HE 20x (4202)

Another case of anaplastic large cell T lymphoma (forearm): Anaplastic large T cell lymphoma, HE 20x (5010)

Another case of anaplastic large cell T lymphoma: Anaplastic large T cell lymphoma, HE 20x (6167)

Another case of anaplastic large cell T lymphoma: Anaplastic large cell lymphoma T (ALCL T), HE 20x (14217) Anaplastic large cell lymphoma T (ALCL T), HE 60x (14218) Anaplastic large cell lymphoma T (ALCL T), CD20 20x (14216) Anaplastic large cell lymphoma T (ALCL T), CD30 20x (14215)

Anaplastic large cell T lymphoma, CD30+, 9 year old boy: Anaplastic large cell lymphoma T (ALCL T), HE 60x (6253) Anaplastic large cell lymphoma T (ALCL T), CD3 40x (6263) Anaplastic large cell lymphoma T (ALCL T), CD30 40x (6262) Anaplastic large cell lymphoma T (ALCL T), CD20 40x (6261) Anaplastic large cell lymphoma T (ALCL T), Ki67 40x (6264)

Anaplastic large cell T lymphoma, CD30+: Anaplastic large cell T lymphoma, CD30+, HE 60x (6292) Anaplastic large cell T lymphoma, CD30+, CD30 40x (6289) Anaplastic large cell T lymphoma, CD30+, granzyme 40x (6290) Anaplastic large cell T lymphoma, CD30+, perforin 40x (6291)

Anaplastic large cell T lymphoma, CD30+: Large cell anaplastic T lymphoma, CD30+, HE 60x (14103) Large cell anaplastic T lymphoma, CD30+, CD3 20x (14102) Large cell anaplastic T lymphoma, CD30+, CD20 20x (14100) Large cell anaplastic T lymphoma, CD30+, CD30 20x (14101) Large cell anaplastic T lymphoma, CD30+, AE13 20x (14099)

Anaplastic large cell T lymphoma (TdT positive?, unusual): ALL T, HE 40x (10124) ALL T, CD3 40x (10122) ALL T, TdT 40x (10126) ALL T, CD20 40x (10121) ALL T, CD79a 40x (10123) ALL T, Ki67 40x (10125)