Pathology
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Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Granular cell tumor, Abrikosoff
Clinical signs
  • location: subcutaneous tissue, oral mucosa
  • asymptomatic nodules, size up to 2 cm
  • age: usually adults, but inborn forms exist
  • malignant variant is very rare
Histology

The tumor consists of roundish cells with broad, granular cytoplasm and small, regular, centrally located nuclei. S100 protein, NSE and PGP 9.5 are usually positive.

Pseudoepitheliomatous hyperplasia of overlying skin or mucosa is common.

Granular cell tumor (4113)

Granular cell tumor (4100)

Granular cell tumor, S100 (4072)

Granular cell tumor (10578)

Granular cell tumor (10579)