Clinical signs:
Therapy:
Therapy based on LCH III. was administered (12 months), with good clinical and radiological response (NAD). Therapy was well tolerated, EFS 18 months on last check-up.
Histology:
Dense infiltrate of histiocytes with many Touton cells, which was CD68 positive and S100 as well as CD1a negative.
Conclusion:
The case was closed as disseminated juvenile xanthogranuloma (xanthoma disseminatum).
Pictures
Disseminated juvenile xanthogranuloma/xanthoma disseminatum:
Disseminated xanthoma, HE 60x (73927)Disseminated xanthoma, HE 60x (73926)Juvenile xanthogranuloma after ALL therapy, S100 40x (73934)Juvenile xanthogranuloma after ALL therapy, Ki67 40x (73933)
Trepanobiopsy:
Multicentric histiocytosis, PAS 60x (73766)Multicentric histiocytosis, CD68 60x (73775)